Bioactive Small Molecules
Cayman Chemical Genz-644282 25mg
An inhibitor of topoisomerase I that inhibits topoisomerase I-mediated DNA cleavage 10-fold more potently than topotecan; inhibits the growth of and is cytotoxic to human and mouse bone marrow cells in vitro (IC50s = 0.4 and 2.3 nM, respectively; IC90s = 1.2 and 8.4 nM, respectively); inhibits the growth of and is cytotoxic to human tumor cell lines in vitro (IC50s = 0.15-2 nM; IC90s = 0.7-8.3 nM); inhibits tumor growth in mouse xenograft models (1.36-2.7 mg/kg)
Cayman Chemical SEL120-34AhydrochlorIde 5mg
A dual inhibitor of Cdk8 and Cdk19 (IC50s = 4.4 and 10.4 nM, respectively); selective for Cdk8 and Cdk19 over a panel of CDK/cyclin complexes at 1 µM; inhibits IFN-γ-induced phosphorylation of STAT1 in HCT116 colon cancer cells at 0.1-5 µM; inhibits proliferation of MOLM-16, MV4-11, and KG-1 cells (GI50s = <1 µM); reduces tumor growth in a KG-1 mouse xenograft model at 60 mg/kg
Medchemexpress LLC Calcium propionate | 4075-81-4 | 99.0% | 100 G
Calcium propionate is an orally active auxiliary agent that helps prevent milk fever and improve the health of dairy cows. It is suitable for research applications related to dairy cow milk fever and subclinical hypocalcemia.
- Orally active auxiliary agent
- Prevents milk fever in dairy cows
- Improves dairy cow health
- Suitable for research on dairy cow milk fever
- Suitable for research on subclinical hypocalcemia
Medchemexpress LLC Dichlorodiphenylmethane | 2051-90-3 | 5 G
Dichlorodiphenylmethane is a drug intermediate widely used in the fields of pesticide, dye, and medicine. This product is for research use only and not intended for human use.
- Widely used in pesticide field
- Widely used in dye field
- Widely used in medicine field
- Not intended for human use
Enzo Life Sciences Lovastatin. sodium salt (5mg). CAS: 75225-50-2
Active carboxylate form of Lovastatin (BML-G226). Active in whole cells as well as cell-free assays. Inhibits cholesterol/ isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase. Alternative name: Mevinolin . sodium salt, 6-alpha-Methylcompactin . sodium salt. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO (10mg/ml) or 100% ethanol (10mg/ml). Long Term Storage: -20°C.
Cayman Chemical ANTIBODY M2698 10mg
A dual inhibitor of p70S6K and Akt1 (IC50s = 1.1 and 4 nM, respectively); selective for p70S6K and Akt1 over Aurora B kinase (IC50 = 170 nM), as well as a panel of 265 kinases at 1 µM; inhibits PKA, MSK1, MSK2, PKG1α, PKG1β, and PRKX; reduces tumor volume in A549 and MiaPaCa-2 mouse xenograft models at doses of 20 or 30 mg/kg, respectively
Medchemexpress LLC Ulotaront hydrochloride | 1310422-41-3 | 99.9% | 219.73 g/mol | C9H14ClNOS | 5 MG
Ulotaront hydrochloride is a research-stage TAAR1/5-HT receptor-active small molecule provided as the hydrochloride salt for preclinical studies. It is supplied in small quantities for laboratory research and is accompanied by datasheet and safety documentation.
- Purity 99.9%.
- Molecular formula C9H14ClNOS.
- Molecular weight 219.73 g/mol.
- Provided as hydrochloride salt for research use only.
- Supplied in small research pack sizes, including 5 mg.
- Datasheet and safety data sheet available.
Medchemexpress LLC Butanoic acid, 4-(acetylamino)- | 3025-96-5 | MFCD00020552 | 98.0% | 145.16 g/mol | C6H11NO3 | 500 MG
4-Acetamidobutanoic acid (N-acetyl GABA) is a research-grade small molecule and a primary metabolite of gamma-aminobutyric acid (GABA). It has reported antioxidant and antibacterial activities and is intended for biochemical and pharmacological research, including metabolite profiling and receptor studies. The material is supplied as a high-purity solid suitable for analytical and preparative workflows.
- High purity, 98.0%.
- Molecular weight 145.16 g/mol; formula C6H11NO3.
- Suitable for metabolite profiling and receptor pharmacology studies.
- Available in solid quantities for analytical and preparative use.
- COA and SDS available to support quality and safety documentation.
AdipoGen -Potassium citramalate H2O
Chemical. CAS 1030365-02-6. Formula C5H6O5 . 2K . H2O. MW 146.1 . 78.2 . 18.0. Synthetic Building block for synthesis.
Medchemexpress LLC AZD-5991 (S-enantiomer) | 2143061-82-7 | 99.8% | 672.26 g/mol | C35H34ClN5O3S2 | 10 MG
AZD-5991 (S-enantiomer) is the less active stereoisomer of a small-molecule Mcl-1 inhibitor provided for research use. It is characterized in biochemical binding and inhibition assays and includes reported activity values from FRET and SPR assays. Molecular formula C35H34ClN5O3S2 and molecular weight 672.26 g/mol are documented for identity and calculation purposes.
- Stereochemically defined S-enantiomer for targeted stereospecific studies.
- Characterized biochemical activity: IC50 6.3 μM (FRET), Kd 0.98 μM (SPR).
- High purity suitable for research: 99.83% reported.
- Molecular formula and molecular weight provided for planning and analysis.
- Supplied in a small research quantity (10 MG) for preclinical experiments.
Medchemexpress LLC Glycerol | 56-81-5 | 98.91% | 500 MG
Glycerol (Standard) is the analytical standard of Glycerol, intended for research and analytical applications. It is used in sample preparation and gel formation for polyacrylamide gel electrophoresis. This analytical standard is a reference standard supplied for assay and is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard for research
- Used in sample preparation and gel formation
- Reference standard for assays
- Suitable for HPLC, GC, and MS research
Medchemexpress LLC Ethotoin (Peganone) | 86-35-1 | 99.6% | 100 MG
Ethotoin (Peganone) is an orally active anticonvulsant agent utilized in epilepsy research. It is a hydantoin, structurally similar to phenytoin.
- Orally active anticonvulsant agent.
- Used in epilepsy research.
- Similar to phenytoin.
Cayman Chemical ArecaIdIn but-2-ynyl ester 5mg
A muscarinic acetylcholine receptor agonist; binds to M1, M2, and M3 mChARs (pD2s = 7.93, 8.33, and 7.67, respectively); inhibits calcium channel currents in a whole-cell patch clamp assay using primary rat SPG cells (EC50 = 3.6 µM); inhibits transmural nerve stimulation-induced vasodilation in isolated and washed porcine basilar arterial rings (EC50 = 0.5 µM); reduces MAP and BPM in normotensive rats in a dose-dependent manner
Cayman Chemical PAR21-6mouserat 5mg
A peptide agonist of PAR2; induces relaxation in precontracted rat arteries; inhibits keratinocyte growth in the presence and absence of growth factors; inhibits LPS-induced pulmonary neutrophil influx and increases in MMP-2 activity in mice
Medchemexpress LLC Purmorphamine (GMP) | 483367-10-8 | C31H32N6O2 | 100 MG
Purmorphamine (GMP) is a version of Purmorphamine produced according to GMP guidelines. This GMP small molecule acts as an auxiliary reagent for cell therapy manufacturing and functions as a smoothened/Smo receptor agonist with an EC50 of 1 μM.
- Functions as an auxiliary reagent for cell therapy manufacturing.
- Acts as a smoothened/Smo receptor agonist with an EC50 of 1 μM.
- Can generate embryoid bodies from human iPS cells and hESCs.
- Converts hPSCs to NKX2-1 positive MGE cells.
- Promotes ventralization of brain spheroids in differentiation process from hiPSCs.
- Promotes hiPSC differentiation into functional neural tissue.
- Induces hESCs differentiation into dopaminergic neurons.